Vaccine Info

Influenza Vaccines

Influenza vaccines, known as flu shots, protect people against the influenza viruses that research indicates will be most common during the upcoming season. 

Most people over 6 months of age are encouraged to get vaccinated every flu season since influenza infections can create severe consequences. The U.S. CDC’s Advisory Committee on Immunization Practices has made this recommendation since the 2010-11 influenza season.

Most importantly, influenza vaccines do not cause the seasonal flu since they are made with either killed or weakened viruses, says the U.S. CDC.

Flu viruses are classified by proteins on the outer surface of the virus: hemagglutinin (H) and neuraminidase (N). There are 18 different H subtypes and 11 different N subtypes, and viruses can be further broken down into different strains within those subtypes. As an example, there are various strains of the H1N1 influenza virus. The H protein (also called HA) enables the flu virus to enter a human cell. It is made up of a head and a stem.

Seasonal flu vaccines fight infection by inducing antibodies that target the HA head. This region varies season to season, which is why flu vaccines must be updated each year, says the U.S. NIH.

The most common flu shot for the 2020-2021 influenza season in the Northern Hemisphere are quadrivalent vaccines that protect people against 4 viruses; influenza A (H1N1) virus, influenza A (H3N2) virus, and 2 influenza B viruses.

>>  Flu shot appointments can be scheduled at a local Walgreens pharmacy  <<

Quadrivalent Influenza Vaccines For The 2020-2021 Flu Season

6 months and older

  • Afluria is an inactivated quadrivalent influenza vaccine indicated for active immunization against influenza disease caused by influenza virus subtypes A and type B.
  • Fluarix is prepared from influenza viruses propagated in embryonated chicken eggs.
  • Flulaval is a quadrivalent, split-virion, inactivated influenza virus vaccine prepared from virus propagated in the allantoic cavity of embryonated hens’ eggs.

2-49 years of age

  • FluMist is an Intranasal vaccine that is a live quadrivalent vaccine that is formulated to contain four vaccine virus strains.

4 years of age and older

  • Flucelvax is a cell culture-based flu vaccine to help offer protection against 4 flu virus strains 

18-64 years of age

  • Flublok made without the use of eggs and therefore is not subject to the mutations that are sometimes introduced into the vaccine during the process of egg adaptation that can cause the traditional vaccines to be ineffective.

65 years and older

  • Fluad consists of an inactivated, quadrivalent influenza virus antigen produced in eggs and an oil-in-water emulsion adjuvant, MF59C.1.
  • Fluzone High-Dose contains 4 times the antigen of standard-dose inactivated influenza vaccines.

Trivalent Influenza Vaccine For The 2020-2021 Flu Season

65 years and older

  • Fluad consists of an inactivated, trivalent influenza virus antigen produced in eggs and an oil-in-water emulsion adjuvant, MF59C.1.

Influenza Vaccine Discounts

Flu shot discounts are sponsored by GoodRx.

Influenza Diagnostic Tests

Flu tests are sponsored by UltaLabs.

Influenza Medicines

There are several medications such as Tamiflu or Xofluza (Baloxavir Marboxil) that can lessen the severity and duration of the seasonal flu, but they're most effective in the first 48 hours after you experience influenza symptoms. Access to these medicines requires a healthcare provider's prescription. 

Influenza Vaccine News

Influenza news focuses on investigational vaccines in clinical development that are designed to provide protection against seasonal influenza A and B viruses, and there shifted or drifted variants, including pandemic influenza viruses:

August 10, 2020 - The Alzheimer’s Association indicates these are possible connections between influenza and pneumonia vaccinations with reducing or delaying cognitive decline. Both studies were previewed at AAIC prior to peer-reviewed journal publication.

August 9, 2020 - The University of California announced requirements for flu shots for students, faculty, and staff.

August 7, 2020 - The U.S. CDC reported a total of 187 influenza-associated pediatric fatalities during the 2019-2020 flu season have been reported to CDC.

August 7, 2020 - Researchers at Kanazawa University report in Nano Letters a high-speed atomic force microscopy study on a biological event that occurs when a flu virus enters and infects its host cell. The real-time visualization of influenza A hemagglutinin has enhanced the understanding of the fusogenic transition of HA and its interactions with host endosomes.

August 6, 2020 - A new study concludes that opening clinics dedicated specifically to treating influenza can limit the number of people infected and help to 'flatten the curve,' or reduce the peak prevalence rate. While the work focused on influenza, the findings are relevant for policymakers seeking ways to reduce the impacts of the ongoing COVID-19 pandemic.

August 3, 2020 - The WHO reported influenza activity was reported at lower levels than expected for this time of the year. As an example, in the temperate zones of the Southern Hemisphere, the influenza season has not commenced. And in the temperate zone of the Northern Hemisphere, influenza activity remained at interseasonal levels

July 30, 2020 - Seqirus announced it has begun shipping its portfolio of seasonal influenza vaccines to customers in the U.S. for the 2020/21 influenza season. Seqirus is well-positioned to supply up to 60 million vaccine doses for the U.S. market.

July 28, 2020 - GSK announced it started shipping more than 50 million quadrivalent influenza vaccine doses to US healthcare providers and pharmacies for the 2020-21 flu season. This data indicates a 9% increase from the last flu season.

July 27, 2020 - At the virtual American Heart Association’s Basic Cardiovascular Sciences 2020 Scientific Session, new research found adults age 50+ who did get a flu shot, had better outcomes in the year following vaccination, with a 28% lower risk of heart attack, a 73% lower risk of death, and an 85% lower risk of cardiac arrest.

July 9, 2020 - An analysis published by the NEJM showed that children 2 to 5 years old with birthdays in September through December were more likely to receive influenza vaccination and less likely to have influenza than those with birthdays earlier in the year before a vaccine is available.

July 9, 2020 - A new study found that among adults obesity is associated with susceptibility to H1N1pdm infection and with symptoms associated with H1N1pdm infection, but not with susceptibility to H3N2 infection or associated symptoms.

July 2, 2020 - the U.S. FDA issued an emergency use authorization for the 3rd diagnostic test for detection and differentiation of the viruses that cause flu and COVID-19 in individuals suspected of COVID-19 disease. The FDA has previously issued authorizations to BioFire Diagnostics LLC and QIAGEN GmbH for their tests, which include many other respiratory organisms in addition to the viruses that cause flu and COVID-19.

February 21, 2020 -  According to the CDC Morbidity and Mortality Weekly Report, the current influenza vaccine has been 45% effective overall against 2019-2020 seasonal influenza A and B viruses.

Universal Influenza Vaccine Research

A key focus of influenza research program is developing a universal flu vaccine that provides robust, long-lasting protection against multiple subtypes of flu, rather than a select few. Such a vaccine would eliminate the need to update and administer the seasonal flu vaccine each year and could provide protection against newly emerging flu strains, potentially including those that could cause a flu pandemic.

Note: This content is aggregated from the US FDA, CDC, research studies, pharmaceutical manufacturers, and the news network. The content is reviewed by healthcare providers, such as Dr. Robert Carlson.

08/11/2020 - 12:41