Vaccine Info

Fluzone Influenza Vaccines

Authored by
Last reviewed
March 9, 2021

Fluzone Influenza Vaccine Description

Fluzone Quadrivalent contains the 2 strains of influenza A, and B identified for the current flu season. The vaccine is given to people 6 months of age and older.

Fluzone High-Dose is a vaccine given to people 65 years of age and older that also contains 4 killed flu virus strains. 

Fluzone High-Dose contains four times the antigen (the part of the vaccine that helps your body build up protection against flu viruses) of standard-dose inactivated influenza vaccines.

The higher dose of antigen in the vaccine is intended to give older people a better immune response and better protection against flu.

For 2020-2021, the quadrivalent (four-component) egg-based vaccines protect against a second lineage of B viruses.

Fluzone Influenza Vaccine Indication

​​​​​Fluzone Quadrivalent and Fluzone High-Dose vaccines help prevent influenza disease caused by influenza A and B strains contained in each vaccine.

Fluzone Quadrivalent is approved to help protect eligible people 6 months and older. Fluzone High-Dose is specifically formulated for people 65+ containing 4X the standard dose. It’s proven to be 24.2% more effective than the standard-dose Fluzone vaccine in preventing the flu.

Fluzone Influenza Vaccine News

March 8, 2021 - Certain patients have an increased risk of influenza infections and poor serologic response to standard influenza vaccination. A new study found tandem high-dose influenza vaccination leads to more robust and more durable seroprotection in high-risk patients.

October 7, 2020 - High-dose flu vaccine in short supply in some places.  If the high-dose vaccine is not available, the CDC recommends getting the regular dose.