Vaccine Info

Engerix-B Hepatitis B Vaccine

Description

Engerix-B a Hepatitis B Vaccine (Recombinant) is a noninfectious recombinant DNA hepatitis B vaccine.

It contains purified surface antigen of the virus obtained by culturing genetically engineered Saccharomyces cerevisiae cells, which carry the surface antigen gene of the hepatitis B virus.

The surface antigen expressed in Saccharomyces cerevisiae cells is purified by several physicochemical steps and formulated as a suspension of the antigen adsorbed on aluminum hydroxide. The procedures used to manufacture ENGERIX-B result in a product that contains no more than 5% yeast protein. No substances of human origin are used in its manufacture.

Indication

Engerix-B is a vaccine indicated for immunization against infection caused by all known subtypes of hepatitis B virus. 

As hepatitis D (caused by the delta virus) does not occur in the absence of hepatitis B infection, it can be expected that hepatitis D will also be prevented by ENGERIX-B vaccination.

Dosage

Engerix-B is administered as an intramuscular injection.

Primary immunization for infants (born of hepatitis B surface antigen [HBsAg]-negative or HBsAg-positive mothers), children (birth through 10 years), and adolescents (aged 11 through 19 years) consist of a series of 3 doses (0.5 mL each) given on a 0-, 1-, and 6-month schedule. 

Primary immunization for persons aged 20 years and older consists of a series of 3 doses (1 mL each) given on a 0-, 1-, and 6-month schedule.

Updated
August 7th, 2019