ChiroRab Rabies Vaccine Description
Chirorab, previously known as Rabipur, is an inactivated rabies virus of the strain Flury LEP. Chiron Behring Vaccines is re-launching Rabipur, which is a purified chick embryo cell (PCEC) vaccine.
Chirorab Vaccine is given to people who are at higher risk of coming in contact with rabies-like veterinarians. It is also given to people after an animal bite if the animal could have rabies. If the vaccine is given immediately and appropriately, it is 100 percent effective.
Chirorab Vaccine is given by injection by a doctor or nurse, administered post thorough washing (for about 15 minutes, with soap and copious amounts of water) of all bite wounds as early as possible. The sooner treatment is begun after exposure, the better.
Chiron Behring Vaccines are manufactured at its WHO pre-qualified facility in Ankleshwar, Gujarat. Bharat Biotech acquired the company in 2019.
ChiroRab Rabies Vaccine Indication
Chirorab is a vaccine that is used for active pre and post-exposure immunization against Rabies. Post-exposure anti-rabies vaccination should always include administration of both Immunoglobulin and vaccine, except for persons who have previously received complete vaccination regimens. It is very, very important to complete the course of the vaccine to prevent this fatal disease.
Chirorab may be used to boost individuals previously immunized with any human diploid cell rabies vaccine.
ChiroRab Rabies Vaccine Dosage
The immunogenicity, efficacy, and safety of Chirorab have been assessed in several clinical trials in pre-and post-exposure regimens, using both intramuscular and intradermal routes of administration.
ChiroRab Rabies Vaccine Adverse Reactions
Anaphylactic reactions, including anaphylactic shock that are rare but clinically severe and potentially lethal, systemic allergic reactions, can occur following vaccination.
Mild allergic reactions, including rashes (widespread) and urticaria (common), may occur after vaccination. These reactions are usually mild in nature and typically resolve within a few days.
Sporadic cases with symptoms of Encephalitis and Guillain-Barré Syndrome have been reported.
In clinical trials, the most commonly reported solicited adverse reactions were injection site pain (30-85%) or injection site induration (15-35%). Most injection site reactions were not severe and resolved within 24 to 48 hours.
ChiroRab Rabies Vaccine News
December 29, 2020 - Indian Scientists discover rabies virus effect on host brain, step closer to cure. After entering into the body, the virus remains dormant for periods ranging from 20 days to even 90 days without showing any clinical symptoms. When symptoms do emerge, there is not much time available to offer any effective treatment. Death occurs within two to seven days. Fatality is thus almost 100 percent.
November 13, 2019 - Chiron Behring Vaccines, part of Bharat Biotech International Ltd., announced the relaunch of Rabipur as Chirorab. “In our ongoing commitment to address the supply shortages of rabies vaccine, we are making additional investments to increase production capacities to over 15 million doses annually,” said Dr. Krishna Ella, CMD, Bharat Biotech.
ChiroRab Rabies Vaccine Clinical Trials
Clinical Trial NCT02545517: A Clinical Study to Evaluate Immune Responses to Rabies Vaccine in Adults Who Received Different Primary Rabies Vaccination Regimens - Last Updated Post: December 24, 2020.