Vaccine Info

ChiroRab Rabies Vaccine

Last Reviewed
February 15, 2021

ChiroRab Rabies Vaccine Description

Chirorab, previously known as Rabipur, is an inactivated rabies virus of the strain Flury LEP.

Chiron Behring Vaccines is re-launching Rabipur, which is a purified chick embryo cell (PCEC) vaccine. It will continue to be manufactured at its WHO pre-qualified facility in Ankleshwar, Gujarat.

ChiroRab Rabies Vaccine Indication

Chirorab is a vaccine that is used for active pre and post-exposure immunization against Rabies.

ChiroRab Rabies Vaccine Dosage

The immunogenicity, efficacy, and safety of Chirorab have been assessed in several clinical trials in pre-and post-exposure regimens, using both intramuscular and intradermal routes of administration.

Chirorab may be used to boost individuals previously immunized with any human diploid cell rabies vaccine.

Post-exposure prophylaxis should commence as soon as possible after exposure.

ChiroRab Rabies Vaccine Adverse Reactions

Anaphylactic reactions, including anaphylactic shock that are very rare but clinically severe and potentially lethal, systemic allergic reactions, can occur following vaccination.

Mild allergic reactions, including rashes (very common) and urticaria (common), may occur after vaccination. These reactions are usually mild in nature and typically resolve within a few days.

Very rare cases with symptoms of Encephalitis and Guillain-Barré Syndrome have been reported. 

In clinical trials, the most commonly reported solicited adverse reactions were injection site pain (30-85%) or injection site induration (15-35%). Most injection site reactions were not severe and resolved within 24 to 48 hours.

ChiroRab Rabies Vaccine News

December 29, 2020 - Indian Scientists discover rabies virus effect on host brain, step closer to cure. After entering into the body, the virus remains dormant for periods ranging from 20 days to even 90 days without showing any clinical symptoms, and when symptoms do emerge, there is not much time available to offer any effective treatment. Death occurs within two to seven days. Fatality is thus almost 100 percent. 

November 13, 2019 - Chiron Behring Vaccines, part of Bharat Biotech International Ltd. announced the relaunch of Rabipur as Chirorab.

“In our ongoing commitment to address the supply shortages of rabies vaccine, we are making additional investments to increase production capacities to over 15 million doses annually,” said Dr. Krishna Ella, CMD, Bharat Biotech.

ChiroRab Rabies Vaccine Clinical Trials

Clinical Trial NCT02545517: A Clinical Study to Evaluate Immune Responses to Rabies Vaccine in Adults Who Received Different Primary Rabies Vaccination Regimens

GlaxoSmithKline (GSK) Biologicals' Rabipur vaccine is indicated for active immunization against rabies in individuals of all ages.

This includes pre-exposure prophylaxis (PrEP), in both primary series and booster dose, and post-exposure prophylaxis.

The aim of this extension study is to evaluate the long-term (up to approx.10 years) persistence and to assess the boostability of immune responses in subjects who received a primary series of accelerated or conventional rabies PrEP IM regimen. No new subjects were enrolled in this study.