Vaccine Info

VRC5283 Zika Virus Vaccine

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Last reviewed
December 5, 2022

VRC5283 Zika Virus Vaccine Description 2022

VRC5283 is a Zika Virus DNA Vaccine candidate.  It is composed of a single closed-circular DNA plasmid that encodes with wild type precursor transmembrane M and envelope proteins from the H/PF/2013 strain of ZIKV.  The vaccine was developed by the Vaccine Research Center (VRC), NIAID

VRC5283 Indication

VRC5283 is a new vaccine candidate that instructs the body to make a small amount of Zika virus protein. The body may use this to build an immune response.

VRC5283 Dosage

The vaccine is supplied in single-dose vials at a concentration of 4 mg/mL. ZIKV DNA vaccine dose will be 4 mg administered as an intramuscular (IM) injection in the deltoid muscle.

VRC5283 News 2017 - 2022

December 4, 2017 - Gene-based Zika vaccine is safe and immunogenic in healthy adults

VRC5283 Clinical Trials

VRC5283 has completed two clinical trials.