Vaccine Info

mRNA-1944 Chikungunya Vaccine

mRNA-1944 Vaccine Description

mRNA-1944 encodes a fully human IgG antibody originally isolated from B cells of a patient with a prior history of potent immunity against Chikungunya infection.

It is composed of two mRNAs that encode the heavy and light chains of this anti-Chikungunya antibody within lipid nanoparticle (LNP) technology.

mRNA-1944 Vaccine Indication

mRNA-1944 is a developmental vaccine candidate to prevent disease caused by the Chikungunya virus

mRNA-1944 Vaccine Updates

September 17, 2020 - Moderna announced positive data from additional cohorts of the Phase 1 study evaluating escalating doses of antibody against the chikungunya virus (mRNA-1944) administered via intravenous infusion in healthy adults. Neutralizing antibodies were observed at all dose levels, indicating functional antibody production by mRNA-1944. 

January 2019, Moderna announced the initiation of a limited, Phase 1 study of mRNA-1944 against the chikungunya virus. 

mRNA-1944 Vaccine Clinical Trials

Clinical Trial NCT03829384:  Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-1944 in Healthy Adults

  • This phase 1 clinical trial is a single-center, randomized, placebo-controlled, dose escalation study to evaluate the safety, tolerability, PK, and PD of a single dose of mRNA 1944 in healthy adult subjects.
  • Cohorts of mRNA-1944 are planned to be investigated in a sequential dose escalation manner.