M-M-R II Vaccine Description
Merck's M-M-R II vaccine is also known as Measles, Mumps, and Rubella Virus Vaccine Live, is a live virus vaccine, containing weakened forms of measles virus, mumps virus, and rubella virus. M-M-R II works by helping the immune system protect itself from these viruses.
Clinical studies of 284 triple-seronegative children 11 months to 7 years of age demonstrated that M-M-R®II is highly immunogenic and generally well-tolerated. In these studies, a single injection of the vaccine-induced measles hemagglutination-inhibition (HI) antibodies in 95%, mumps neutralizing antibodies in 96%, and rubella HI antibodies in 99% of susceptible persons. However, a small percentage (1%-5%) of vaccinees may fail to seroconvert after the primary dose.
M-M-R II Vaccine Indication
It is indicated for simultaneous vaccination against measles (rubeola), mumps, and rubella (German measles). This vaccine is usually given to people one-year-old or older.
M-M-R II is contraindicated in certain individuals, including those with: a history of hypersensitivity to any component of the vaccine, including gelatin; a history of anaphylactic or anaphylactoid reaction to neomycin; blood dyscrasias, leukemia, lymphomas of any type, or other malignant neoplasms affecting the bone marrow or lymphatic systems; primary or acquired immunodeficiency conditions; family history of congenital or hereditary immunodeficiency or receiving immunosuppressive therapy; an active febrile illness; or those who are pregnant. If vaccination of postpubertal females is undertaken, pregnancy should be avoided for 3 months following vaccination.
M-M-R II Vaccine Dosage
The ACIP recommends administration of the first dose of M-M-R®II at 12 to 15 months of age and administration of the second dose of M-M-R®II at 4 to 6 years of age.
The M-M-R II vaccine is given as a shot administered subcutaneously, preferably into the outer aspect of the arm. The dose of the vaccine is the same for everyone. If your child gets the shot when he or she is one year old or older, a second dose is recommended.
Often, the second dose is given right before the child goes to elementary school (4 to 6 years of age). If your child is less than one year old when he or she first gets the shot, a second dose should be given when they are 12 to 15 months old.
Then, a third shot should be given between 4 and 6 years of age. Your doctor will decide the best time and number of shots by using official recommendations.
M-M-R II Vaccine News
May 18, 2020 - Routine vaccinations for young children in the U.S. fell during the first half of this year as more Americans skipped routine doctor visits due to the coronavirus pandemic, according to a report published Monday by the Centers for Disease Control and Prevention.
May 3, 2020 - The report MMR Vaccine Link to COVID-19: Fewer Deaths and Milder Cases from SARS-CoV-2 in Measles-Rubella Vaccinated Populations reveals that the MMR vaccine launched in 1971 (49 years ago) could explain why those 49 and under are much less likely to have bad outcomes from COVID-19 compared to those 50 and over, according to report co-contributor Dr. Larry P. Tilley, an Advisory Board Member of World Organization.
April 28, 2020 – Public health officials in Mexico have identified a measles virus outbreak in various states in Mexico.
April 27, 2020 – A new review of the existing evidence on the safety and effectiveness of measles-related vaccines supports their continued use for mass immunization around the world.
M-M-R II Vaccine Clinical Trials
Clinical Trial NCT01702428: Consistency Study of GlaxoSmithKline (GSK) Biologicals' MMR Vaccine (209762) (Priorix) Comparing Immunogenicity and Safety to Merck & Co., Inc.'s MMR Vaccine (M-M-R II), in Children 12 to 15 Months of Age