EXD-12 is a live attenuated herpes simplex vaccine candidate. EXD-12 is going to be tested as a prophylactic and therapeutic vaccine candidate in the guinea pig model.
EXD-12 is currently in preclinical testing for safety and efficacy as both a prophylactic and therapeutic vaccine for both Herpes Simplex Virus-1, HSV-1, and Herpes Simplex Virus-2, HSV-2.
There is no cure for herpes. However, there are medicines that can prevent or shorten outbreaks.
Oral herpes is usually caused by HSV-1 and can result in cold sores or fever blisters on or around the mouth. However, most people do not have any symptoms. Most people with oral herpes were infected during childhood or young adulthood from non-sexual contact with saliva.
Genital herpes is common in the United States. More than one out of every six people aged 14 to 49 years have genital herpes. You can get genital herpes by having vaginal, anal, or oral sex with someone who has the disease.
HSV-2 infection is more common among women than among men; the percentages of those infected during 2015-2016 were 15.9% versus 8.2% respectively, among 14 to 49 year olds. 2 This is possibly because genital infection is more easily transmitted from men to women than from women to men during penile-vaginal sex.
Most people who have genital herpes have no symptoms or have very mild symptoms. You may not notice mild symptoms or you may mistake them for another skin condition, such as a pimple or ingrown hair. Because of this, most people who have herpes do not know it.
Herpes sores usually appear as one or more blisters on or around the genitals, rectum or mouth. The blisters break and leave painful sores that may take a week or more to heal. These symptoms are sometimes called “having an outbreak.” The first time someone has an outbreak they may also have flu-like symptoms such as fever, body aches, or swollen glands.
People who experience an initial outbreak of herpes can have repeated outbreaks, especially if they are infected with HSV-2. Repeat outbreaks are usually shorter and less severe than the first outbreak. Although the infection stays in the body for the rest of your life, the number of outbreaks may decrease over time.
Neonatal herpes is one of the most serious complications of genital herpes. Healthcare providers should ask all pregnant women if they have a history of genital herpes. Herpes infection can be passed from mother to child during pregnancy or childbirth, or babies may be infected shortly after birth, resulting in a potentially fatal neonatal herpes infection. Infants born to women who acquire genital herpes close to the time of delivery and are shedding virus at delivery are at a much higher risk for developing neonatal herpes, compared with women who have recurrent genital herpes.
December 17, 2019: The company indicates initial study results may be published in early 2020.
September 14th, 2018: Excell files a new provisional patent application with the United States Patent and Trademark office for their EXD-12 HSV vaccine candidate.
New data indicates that glycoprotein D acts as a decoy, so the immune system is not able to form an effective antibody response to other antigens. Without glycoprotein D, Herpes is visible to the immune system and is also unable to spread between cells.