Bexsero Meningitis B Vaccine Description - 2022
GSK's Bexsero vaccine contains proteins from group B Neisseria meningitidis bacteria. The combination of proteins was chosen to protect against most MenB strains.
Apart from active ingredients, the vaccine contains minimal amounts of these ingredients: Aluminium which strengthens and lengthens the immune response to the vaccine, salt (sodium chloride), sugar (sucrose), and an amino acid called histidine, both used as acidity regulators. Therefore, anyone allergic to these ingredients or who had a severe allergic reaction after a previous dose should not receive BEXSERO.
Bexsero (Meningococcal Group B Vaccine) suspension for intramuscular injection was initially approved in the USA in 2015. The approval of BEXSERO is based on the demonstration of the immune response, as measured by serum bactericidal activity against three serogroup B strains representative of prevalent strains in the United States. The effectiveness of BEXSERO against diverse serogroup B strains has not been confirmed.
The U.S. CDC's Advisory Committee on Immunization Practices recommends routine vaccination with a quadrivalent meningococcal conjugate vaccine (MenACWY) for adolescents aged 11 or 12, with a booster dose at age 16. And for people between 16 to 23 receive the Bexsero vaccine based on "shared clinical decision-making." The CDC's 2022 vaccination schedule was posted on February 17, 2022. The GSK vaccination schedule was updated in 2021.
Evidence that the MeNZB and four-component serogroup B meningococcal (4CMenB) vaccines can also offer protection against gonorrhea has created interest in using 4CMenB for this purpose and for developing gonorrhea-specific vaccines.
UK-based GSK is the producer of Bexsero. DrugBank Accession Number: DB10786
Bexsero Meningitis B Vaccine Indication
Bexsero is an FDA-approved vaccine to prevent invasive diseases caused by Neisseria meningitidis serogroup B. Bexsero was approved for use in 2015 for individuals 10 through 25 years of age. The Meningococcal B vaccine can help protect against meningococcal disease caused by serogroup B. According to the U.S. CDC, a different meningococcal vaccine is available that can help protect against serogroups A, C, W, and Y. Bexsro is contraindicated in cases of hypersensitivity, including severe allergic reaction, to any component of the vaccine or after a previous dose of BEXSERO.
An observational study of 16-23-year-olds in New York City and Philadelphia from 2016-to 2018 indicates receiving two doses of the meningitis vaccine 4CMenB provides 40% protection against gonorrhea. Outer membrane vesicle meningococcal serogroup B vaccines might be protective against gonorrhea.
Bexsero Meningitis B Vaccine Dosage
Bexsero is for intramuscular use only. The two doses of Bexsero can be completed in 1 month.
Bexsero Meningitis B Vaccine News For 2020 - 2022
April 27, 2022 - GSK reported meningitis vaccine sales grew 12% AER, 12% CER% to £212 million, mainly driven by Bexsero (22% AER, 23% CER to £163 million), reflecting higher U.S. CDC purchasing.
April 12, 2022 - The Lancet published a study that concluded complete vaccination with the four-component meningococcal serogroup B vaccine (Bexsero) provided 40% protection against gonorrhea infection compared with no vaccination (adjusted prevalence ratio [APR] 0.60, 95% CI 0.47-0.77, P<0.0001). This finding indicates that the MenB-4C vaccine could offer cross-protection against Neisseria gonorrhoeae.
February 21, 2022 - The UK government published the new 2022 routine immunization schedule. This schedule includes selected programs and additional vaccines recommended for individuals with underlying medical conditions.
February 9, 2022 - GSK reported during 2021, Bexsero sales were stable at AER but grew 5% CER to £650 million, reflecting increased market share in the US.
September 18, 2021 - The WHO reported a total of 608 suspected, including 12 confirmed cases of meningitis, and 161 deaths (case fatality ratio of 26%), have been reported in the Banalia health zone of the Democratic Republic of the Congo. Among these cases, 68% are aged 15 years or older.
September 8, 2021 - The World Health Organization in Africa reported that the Democratic Republic of the Congo had declared a Neisseria meningitidis outbreak in the north-eastern Tshopo Province. About 261 suspected cases and 129 deaths have been reported.
August 26, 2021 - GlaxoSmithKline is promoting the distinction between the common MenACWY vaccine for adolescents and the separate MenB vaccine for older teens. Lending GSK's "Ask2BSure" campaign is former child actor Soleil Moon Frye, who starred in the popular '80s show "Punky Brewster."
July 28, 2021 - GSK reported financial results. Menveo sales were up 55% AER, 71% CER to £59 million, primarily driven by higher demand in the U.S., partly offset by unfavorable phasing and lower demand in International.
June 28, 2021 - The U.K. published: A Freedom of Information request on a detailed report of the vaccine injuries and deaths of the Bexsero vaccine since it came out in 2016 (FOI 21-364).
December 1, 2020 - Meningococcus group B, the most prevalent strain of the meningococcal infection, is prevented with 79% effectiveness in children and young adults inoculated with the 4CMenB vaccine, also known as Bexsero, according to a new collaborative study from researchers in Portugal and the U.K. and led by the University of Bristol which evaluated the vaccine's performance in a real-world setting. This matched case-control study published by the JAMA that included 299 children, the likelihood of full vaccination with 4CMenB among children old enough to be fully immunized was significantly lower among cases with group B invasive meningococcal disease compared with controls without the invasive meningococcal disease (odds ratio, 0.21). Furthermore, 11 children with meningococcal infection who had received at least one dose of the 4CMenB vaccine survived, and none were left with related disabilities. In contrast, among the remaining 87 cases who were unvaccinated, seven died, and 16 suffered long-term injuries, suggesting that the vaccinated cases may have been partially protected. This finding means that during the first 5 years of vaccine availability in Portugal, full vaccination with 4CMenB was less likely among children who developed group B invasive meningococcal disease than matched controls.
Bexsero Meningitis B Vaccine Clinical Trials
Bexsero Meningitis B Vaccine Has been tested in over 80 clinical studies.