Ad5-EBOV Vaccine Description
Ad5-EBOV is an adenovirus type 5 vector-based Ebola virus disease vaccine that protects against Ebola by relying on the recombinant replication-defective human adenovirus type-5 vector to induce an immune response.
CanSino Biologics's Ad5-EBOV received approval in China in October 2017.
In 2014, a single-center, double-blind, placebo-control, dose-escalation phase 1 clinical trial was performed in Taizhou, China. The findings showed that the Ad5-EBOV vaccine was safe and robustly immunogenic. The investigators intended to evaluate the safety and immunogenicity of a booster dose of the recombinant Ebola adenovirus vector vaccine (Ad5-EBOV) in healthy adults after primary immunization in this add-in study. The investigators expect that the boosting immunization with the same vaccine for primary immunization is possible and could confer longer-lived protection when needed.
During July 2015, the First Affiliated Hospital of Zhejiang University launched a single-center, open, dose-escalation phase 1 clinical trial. This study will determine the safety and side-effect profile, and immunogenicity of an investigational Ad5-EBOV vaccine in Healthy Adult Africans aged between 18-60 years in China.
Ad5-EBOV has shown an acceptable stability profile and does not require ultra-low temperature storage conditions.
CanSino Biologics Inc.'s Ad5-EBOV is currently for national Chinese stockpile and has the potential for international stockpile opportunities.
Ad5-EBOV Vaccine Indication
Ad5-EBOV is indicated to prevent an infection of the Ebola disease. One shot of the high dose vaccine could mount glycoprotein-specific humoral and T-cell response against the Ebola virus in 14 days.
Ad5-EBOV Vaccine Clinical Trials
Clinical Trial NCT02401373: A Phase I Trial to Evaluate Ad5-EBOV in Healthy Adult Africans in China (Competed)
Clinical Trial NCT02533791: A Booster Dose of Ad5-EBOV in Healthy Adults After Primary Immunization
Ad5-EBOV Vaccine News
August 12, 2020 - CanSino Biologics Inc., announced that it has successfully listed on the Sci-Tech Innovation Board (STAR Market) of the Shanghai Stock Exchange, making it the first "A+ H" dual listing vaccine company.
August 19, 2019 - Overview of candidate Ebola vaccines was published by the WHO.
October 24, 2017 - Ad5-EBOV, the recombinant adenovirus vector-based vaccine is the first Ebola shot based on the strain behind the recent epidemic in West Africa in 2014—the deadliest outbreak in recorded history.
October 14, 2014 - A Booster Dose of Ad5-EBOV in Healthy Adults After Primary Immunization.