Vaccine Info

Vitagerpavac Herpesvirus Vaccine

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Last reviewed
September 5, 2021
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Vitagerpavac Herpesvirus Vaccine Description

Vitagerpavac is a multivalent vaccine for treating chronic herpesvirus infection (HCV) of types I and II. Vitaherpavac is a dry, inactivated herpes simplex virus (HSV) culture vaccine that has been obtained by using the Vero B continuous cell line as a substrate for the accumulation of herpes simplex virus types 1 (US strain) and 2 (VN strain).

The vaccine stimulates body mechanisms of cellular resistance to herpes simplex virus type 1 and type 2. The tolerability and therapeutic effectiveness of the vaccine were tested in patients diagnosed as having chronic, frequently recurring herpes.

The clinical trials have yielded positive results that suggest it is expedient to introduce the new Vitaherpavac into practice to treat chronic recurrent herpetic infection of various localizations. 

The vaccine was developed at the Research Institute of Virology. DI. Ivanovsky RAMS and has been used in the Russian Federation for over 15 years. Approved by the Ministry of Health in the form of guidelines of the Russian Federation MR 3.3.1.0002-10 "Immunization with the" Vitagerpavac "vaccine. ATX codeJ07BX 

JSC "FIRM" VITAFARMA ", 125040, Moscow, 1st street Yamskogo Polya.

Vitagerpavac Herpesvirus Vaccine Indication

This Russian vaccine is indicated to prevent the chronic herpes virus infection of HSV1 and HSV2.  It is indicated for patients with a chronic herpes infection in remission.

Contraindications for vaccination: active herpes infection (relapse), acute infectious and non-infectious diseases, chronic diseases in the acute stage, malignant neoplasms, pregnancy, and the presence of active symptoms of AIDS.

Vitagerpavac Herpesvirus Vaccine Dosage

The vaccination course includes 5 injections carried out at intervals of 7-10 days between injections.

Vaccination is carried out in a medical institution under the supervision of medical staff. The vaccine is used during the remission stage, including ophthalmic herpes, not earlier than 10 days after the complete disappearance of the clinical manifestations of herpes infection. The vaccination course consists of 5 injections with an interval of 7 days, revaccination (repeated administration according to the same course of treatment) - after 6 months.

If, after the 1st or subsequent injections, herpetic infection reoccurs, this means a case of pronounced immunosuppression. In such case, vaccination should be temporarily discontinued, and anti-viral agents containing recombinant alpha-2 interferon (Genferon 500 000 IU suppositories) should be used to suppress the reoccurrence of herpes, 1 suppository 2 times a day for 5-10 days. Then, 10 days after the herpes rash or lesions disappear, the Vitaherpavac course of treatment should be restarted from the beginning.

Coadministration of the Vitaherpavac vaccine and the immunomodulator Giaferon has been shown to have some advantage over the vaccination only. The new formulation of the agent as suppositories (per rectum) enhances the vaccine's immunogenicity and protective properties, reduces the frequency of its application and makes it more convenient for patients to use, says the company.

Vitagerpavac Herpesvirus Vaccine Availability

This vaccine has only been approved for use in Russia. However, according to this website, the product may become available in late 2021.

Vitagerpavac Herpesvirus Vaccine News

September 2009 - Vitaherpavac is the first Russian herpes simplex virus vaccine obtained on the Vero B cell line.

Clinical Trials

No clinical trials found