Typhim VI Vaccine Description
Typhim VI is a sterile solution prepared from the purified polysaccharide capsule of Salmonella typhi (Ty 2 strain). The purified polysaccharide capsule is diluted in an isotonic buffer solution that contains phenol as a preservative, sodium chloride, disodium phosphate dihydrate, monosodium phosphate dihydrate, and water for injection.
Typhim VI protects against the risk of infection related to Salmonella typh i. Still, it does not confer vis-à-vis protection of Salmonella Paratyphi A or B, or non-typhoid salmonella.
First licensed during 1988 in France, the Typhim Vi® vaccine, manufactured at Sanofi Pasteur’s facility in Marcy L’Etoile, France, has established a longstanding safety and seroprotection track record.
Sanofi Pasteur is the vaccines division of the French multinational pharmaceutical company Sanofi.
Typhim VI Vaccine Indication
Typhim VI is indicated for use to protect against Typhoid Fever in adults and children over 2 years of age. Travelers going to endemic areas, migrants, health personnel, and soldiers should consider being vaccinated.
A single injection provides protection; however, if the risk exposure is maintained and depending on the exposure level, revaccination should be performed every 2 to 3 years.
Immunity appears between 1 to 3 weeks after the injection. The term of protection is approximately 3 years.
Typhim VI Vaccine Dosage and Side Effects
Typhim VI is administered as an intramuscular injection or subcutaneous route.
Vaccine efficacy is overall 74% in adults and 55% in children. The safety profile has been reassessed based on clinical studies (15,000 people) and population surveillance.
The most common side effects reported in children and adolescents (aged 2 to 17 years) are injection site reactions (pain: 53%; swelling or induration: 16%; redness: 14%), muscle pain (15%), and headaches (13%). In adults, it is pain at the injection site (76%), muscle pain (47%), and fatigue (25%).
Typhim VI News
February 12, 2021 - U.S. CDC reports Extensively Drug-Resistant Salmonella Typhi Infections Among U.S. Residents Without International Travel.
September 30, 2020 - Travel Alert: Extensively Drug-Resistant Typhoid Fever in Pakistan. The CDC recommends that all travelers (even short-term travelers) to South Asia, including Pakistan, be vaccinated against typhoid fever before travel.
June 23, 2011 - Sanofi Pasteur’s Typhim Vi®, granted prequalification by the WHO. WHO prequalification is a key step that allows for the procurement of vaccines by UNICEF and other United Nations (UN) agencies like the Pan American Health Organization (PAHO) Revolving Fund. It is also a prerequisite for GAVI Alliance New and Underused Vaccines Support for vaccine distribution, ensuring and improving developing countries’ access to vaccines that meet unified quality, safety, and efficacy standards.
Typhim VI Clinical Trials
Clinical Trial NCT02645032: Phase 1 trial of the safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Last Update Posted on April 28, 2020