Vaccine Info

Dexamethasone

Dexamethasone Description

Dexamethasone is a corticosteroid that has been used since the 1960s to reduce inflammation in a range of conditions, including inflammatory disorders and certain cancers. Dexamethasone is in clinical trials to determine its use for patients hospitalized with COVID-19.

Dexamethasone is a steroid that has been used since the 1960s to reduce inflammation in a range of conditions, including inflammatory disorders and certain cancers. It has been listed on the WHO Model List of Essential Medicines since 1977 in multiple formulations and is currently off-patent and affordably available in most countries.

Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It often is used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma.

Dexamethasone may cause side effects.

It is currently off patent which makes it affordably available in most countries.

Dexamethasone Indication

Dexamethasone is indicated for patients hospitalized with COVID-19. 

Dexamethasone reduced 28-day mortality among those receiving invasive mechanical ventilation or oxygen at randomization, but not among patients not receiving respiratory support.

Dexamethasone Dosage

Dexamethasone comes as a tablet and a solution to take by mouth. In the clinical trial, 6 mg of dexamethasone tablet was given once daily for up to ten days.

Dexamethasone News

June 22, 2020 - Recovery Results: 2104 patients randomly allocated to receive dexamethasone were compared with 4321 patients concurrently allocated to usual care. Overall, 454 (21.6%) patients allocated dexamethasone and 1065 (24.6%) patients allocated usual care died within 28 days (age-adjusted rate ratio [RR] 0.83; 95% confidence interval [CI] 0.74 to 0.92; P<0.001).

June 16, 2020 - The World Health Organization (WHO) welcomes the initial clinical trial results from the United Kingdom (UK) that show dexamethasone, a corticosteroid, can be lifesaving for patients who are critically ill with COVID-19.

February 7, 2020 - Dexamethasone Treatment for the Acute Respiratory Distress Syndrome: A Multicentre, Randomised Controlled Trial.

March 27, 2019 - The Effect of Corticosteroids on Mortality of Patients With Influenza Pneumonia: A Systematic Review and Meta-Analysis.

Dexamethasone Clinical Trials

Clinical Trial NCT04381936: Randomised Evaluation of COVID-19 Therapy (RECOVERY)

  • RECOVERY is a randomized trial investigating whether treatment with either Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin, Convalescent plasma or Tocilizumab prevents death in patients with COVID-19.
Updated
06/23/2020 - 10:04