Egaten is currently the only treatment for fascioliasis recommended by the WHO and is on the WHO Model List of Essential Medicines.
Fascioliasis, commonly known as liver fluke infestation, is a neglected tropical disease that currently affects an estimated 2.4 million people worldwide, with an additional 180 million at risk of infection.
It is caused by two species of parasitic flatworms or trematodes that mainly affect the liver (Fasciola hepatica or Fasciola gigantica). Both species can infect humans following ingestion of larvae in contaminated water or food (mainly raw or undercooked vegetation). The larvae mature into adult worms in the biliary tract.