Vaccine Info

VTP-500 (ChAdOx1) MERS Coronavirus Vaccine

Last Reviewed
February 16, 2021

VTP-500 MERS Vaccine Description

VTP-500 (ChAdOx1) MERS is a vaccine candidate to treat MERS Coronaviruses (CoV). The ChAdOx1 MERS vaccine consists of the replication-deficient simian adenovirus vector ChAdOx1, containing the MERS Spike protein antigen.

Vaccitech’s VTP-500 MERS vaccine utilizes the ChAdOx1 virus platform to encode MERS coronavirus spike protein to induce T cells and antibodies that block virus-host cell receptor binding and fusion or neutralize virus infection.

Vaccitech’s partner, the University of Oxford’s Jenner Institute, in collaboration with The King Abdullah International Medical Research Centre (KAIMRC), announced on December 20, 2019, that it has started a Phase I clinical trial in the Kingdom of Saudi Arabia (KSA) for a vaccine against the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Vaccitech retains commercial rights to this vaccine.

The patented Vaccitech adenovirus vectors are known as chimpanzee adenovirus Oxford 1 and 2 (ChAdOx1 and ChAdOx2) and are in the group E simian adenovirus family, similar to the widely-studied chimpanzee adenovirus 63. These viruses have been engineered to be replication-deficient and can be manufactured in well-established HEK293 cell lines containing the adenoviral E1 gene.

Vaccitech has licensed the needed patents from Oxford University to advance its programs. ChAdOx1 vector patent was granted in the US and the EU, and our MVA-NP+M1 patent is granted in the EU and pending in the US.

Oxford, England-based Vaccitech is a T cell immunotherapy and vaccine company originally with the University of Oxford’s Jenner Institute.

VTP-500 MERS Coronavirus Vaccine Indication

VTP-500 (ChAdOx1) is a vaccine candidate that protects people against the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and the novel SARS-CoV-2 coronavirus.

VTP-500 MERS Coronavirus Vaccine News

August 21, 2020 - CEPI, Oxford University, and Janssen have entered into a collaboration worth up to $19M to progress the vaccine through Phase 2 studies and establish a human vaccine stockpile with the University. 

June 10, 2020 - RESEARCH ARTICLE: A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques.

April 17, 2020 - NIH press release: Investigational chimp adenovirus MERS-CoV vaccine protects monkeys. Vaccine neutralizes multiple MERS-CoV strains.

December 20, 2019 - Vaccitech’s partner, the University of Oxford’s Jenner Institute, in collaboration with The King Abdullah International Medical Research Centre (KAIMRC), announced that it had started a Phase I clinical trial in the Kingdom of Saudi Arabia (KSA) for a vaccine against the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Vaccitech retains commercial rights to this vaccine. The trial will be the first Phase I clinical trial ever to be conducted in the KSA and provide valuable clinical data. The trial is a collaboration between the Jenner Institute and the King Abdullah International Medical Research Center (KAIMRC), funded by the Department of Health and Social Care.

November 8, 2019 - Study: Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). The vaccine enhanced antibody responses in seropositive camels; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals, and neutralizing antibodies were detected in nasal swabs.

VTP-500 MERS Coronavirus Vaccine Clinical Trials

Clinical Trial NCT04170829A Clinical Trial to Determine the Safety and Immunogenicity of Healthy Candidate MERS-CoV Vaccine. This research was funded by the Department of Health and Social Care (project number:16/107/01) as part of the UK Vaccine Network (UKVN), a UK Aid program to develop vaccines for diseases with epidemic potential in low and middle-income countries.

Clinical Trial NCT03399578: Safety and Immunogenicity of a Candidate MERS-CoV Vaccine.

CONTENT SOURCES:  World Health Organization, US Centers for Disease Control and Prevention, clinicalTrials.gov, and the Precision Vaccinations news network.