Vaccine Info

TY014 Anti-Yellow Fever Therapeutic Vaccine

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Last reviewed
April 8, 2021

TY014 Anti-Yellow Fever Vaccine Description

TY014 will be the first therapeutic in the world, specifically targeting Yellow Fever Virus (YFV), to enter clinical trials. It is anticipated that a monoclonal antibody therapeutic could be administered to infected cases to reduce disease severity within the patient and their contacts.

TY014 is a fully engineered human IgG1 monoclonal antibody against the yellow fever virus, is manufactured with the use of Chinese hamster ovary cells. It specifically targets a conserved epitope on the yellow fever virus envelope (E) protein. 

Although there is currently a safe and effective vaccine available on the market, global shortages of supplies have severely hampered any efforts in the prevention and control of YFV outbreaks.

To date, no YFV therapy (biologic or small molecule) has advanced to clinical trials. 

TY014 Anti-Yellow Fever Vaccine Indication

TY014 is indicated as a postinfection therapy for yellow fever virus infection.

TY014 Anti-Yellow Fever Vaccine News

July 30, 2020 - Phase 1 Trial of a Therapeutic Anti–Yellow Fever Virus Human Antibody. This phase 1 trial of TY014 did not identify worrisome safety signals and suggested potential clinical benefit, which requires further assessment in a phase 2 trial. 

November 18, 2019 - "Our successful trials pave the way for a potential first-in-class treatment for Yellow Fever. This rapid development following the similar achievement for Zika affirms the exciting collaboration between Tychan and WuXi Biologics to enable a new paradigm to expedite biologics development initiatives to address emerging infectious disease outbreaks and eventually to potentially expand to other therapeutics," said Teo Ming Kian, Chairman of the Board, Tychan.

TY014 Anti-Yellow Fever Vaccine Clinical Trials

Clinical Trial NCT03776786: Safety and Tolerability of an Antibody Against Yellow Fever Virus (TY014) in Humans

This is a Phase 1, first-in-human TY014, YFV monoclonal antibody (mAb), study to be conducted in two (2) arms:

Safety Arm (1A): Healthy adult volunteers

Efficacy Arm (1B): Healthy adult volunteers challenged with YF-17D Vaccine Strain 24 hours prior to TY014 dosing

Clinical Trials

No clinical trials found