Fluzone High-Dose contains 3 killed flu virus strains.
Fluzone High-Dose contains four times the antigen (the part of the vaccine that helps your body build up protection against flu viruses) of standard-dose inactivated influenza vaccines.
For the 2019 Influenza season, the 3 killed viruses were A/Michigan/45/2015 (H1N1)pdm09-like virus (A/Michigan/45/2015 X-275), A/Switzerland/8060/2017 (H3N2)- like virus (A/Brisbane/1/2018 X-311) and B/Phuket/3073/2013-like virus (B/Phuket/3073/2013).
Fluzone High-Dose vaccines are indicated for people 65 years of age and older to help prevent influenza disease caused by influenza A and B strains contained in each vaccine.
The higher dose of antigen in the vaccine is intended to give older people a better immune response, and therefore, better protection against flu.
Fluzone High-Dose is administered as an intramuscular injection.
Fluzone High-Dose vaccine should not be given to anyone who has had a severe allergic reaction (eg, anaphylaxis) to any component of the vaccine (including egg or egg products for Fluzone Quadrivalent and Fluzone High-Dose vaccines) or after a previous dose of the corresponding vaccine.
In addition, Fluzone High-Dose vaccine should not be given to anyone who has had a severe allergic reaction after a previous dose of any influenza vaccine.
Tell your health care professional if you/your child have ever experienced Guillain-Barré syndrome (severe muscle weakness) after a previous dose of influenza vaccine. If you notice any other problems or symptoms following vaccination, please contact your health care professional immediately.
In adults, the most common side effects to Fluzone High-Dose vaccine include pain where the shot was given; headache and muscle aches.