Allergy Vaccine and Hep B Connected
Vaccination with BM32 achieved an average inhibition of hepatitis B virus infection of 80%
A new grass pollen allergies vaccine (BM32) might also offer an effective treatment for combating the hepatitis B infection.
The BM32 vaccine is based on an innovative recombinant peptide-carrier technology, requiring fewer injections. Additionally, may have fewer side-effects.
This is the finding of a study conducted at MedUni Vienna's Institute for Pathophysiology and Allergy Research that has now been published in the leading journal EBioMedicine, with a commentary from international experts.
Recombinant peptide-carrier technology was developed at the Christian Doppler Laboratory for Allergy Research at MedUni Vienna, under the direction of Rudolf Valenta. BM32 was developed jointly with commercial partner Biomay AG.
In a Phase IIb study conducted as part of her dissertation at the Institute for Pathophysiology and Allergy Research at MedUni Vienna, Carolin Cornelius discovered that BM32 is also a highly promising treatment option for combating hepatitis B infections.
Hepatitis B infection is still one of the most widespread health problems in the world. The virus is detectable in the blood of around 350 million people.
However, around 5 to 10% of those who have been vaccinated using a conventional vaccine fail to build up an adequate antibody titer.
Cornelius: "We were able to show that, in people who had not previously been immunised with a conventional hepatitis B vaccine, vaccination with BM32 achieved an average inhibition of hepatitis B virus infection of 80%.”
According to the MedUni Vienna researcher, this suggests that the concept of peptide-carrier fusion proteins might also be a potential approach for improving hepatitis B immunisation.
- Grass pollen allergy vaccine also effective against hepatitis B
- Development of Biomay´s BM32 vaccine for grass pollen allergy progressing according to plan ( 2 Nov. 2010)
- Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy
- Center for Pathophysiology, Infectiology and Immunology (CePII)