MpoxToday March 2023

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Last reviewed
March 20, 2023
Content Overview
Mpox outbreaks began in May 2022 and continues in March 2023. Mpox is a vaccine preventable disease.

MpoxToday March 2023

MpoxToday publishes information people can trust to make informed decisions regarding Mpox virus (MPXV) prevention, treatment, and vaccination.

The World Health Organization (WHO) announced on March 16, 2023, the number of mpox cases continues to slowly decline, with the Americas remaining in the region. Recently, the WHO Director-General transmitted the report of the fourth meeting of the International Health Regulations Emergency Committee in February 2023, reaffirming the public health emergency of international concern in place for mpox.

As of March 2023, the U.S. Centers for Disease Control and Prevention (CDC) confirmed over 110 countries had reported about 86,000 Mpox patients and 88 related fatalities. And the Advisory Committee on Immunization Practices (ACIP) presented: Evidence to Recommendations Framework: Vaccination with JYNNEOS During Mpox Outbreaks.

The Mpox outbreak in the U.S. was first declared in August 2022 and renewed in November 2022. On October 27, 2022, the Mpox public health emergency in San Francisco ended, followed by New York City in November 2022. The CDC posted an explanatory Mpox vaccination video on Twitter on January 20, 2023. It was reported the U.S. HHS did not renew the public health emergency declaration for Mpox on January 31, 2023, given the reduced number of cases in the USA.

On March 3, 2023, the CDC reported possible undetected mpox among three persons experiencing homelessness near San Francisco during the mpox outbreak highlighting the need for tailored outreach strategies that ensure interventions such as prevention messaging and vaccination reach persons experiencing homelessness. In addition, the CDC published - Interim Clinical Treatment Considerations for Severe Manifestations of Mpox on March 3, 2023.

On February 21, 2023, The Lancet published a study that suggests there are mutations in clade IIb that are faster than expected, especially in APOBEC3 enzyme editing. And various countries have reported other lineages (A.2.1, A.2.2, and now A.3) that phylogenetically originate in Nigeria, which suggests sustained transmission in non-MSM groups.

Mpox 2023

Vaccines: Mpox vaccines are authorized and in development. The CDC posted an explanatory Mpox vaccination video on Twitter on January 20, 2023. 

Treatments: Pre-exposure prophylaxis and post-exposure prophylaxis Mpox treatments.

Testing: Diagnostic laboratories offer a variety of tests to identify the infectious status and Mpox virus types.

Research: Unbiased, peer-reviewed clinical research that offers insights into Mpox science.

Disease: Mpox is part of the same family of viruses as the variola virus that causes smallpox.

Mpox Information Sources

Mpox Today's information sources include the WHO, the U.S. CDC, U.S. FDA, European Medicines Agency, and the U.K. Health Services Agency, research publications, academic institutions, and industry participants. Information from these world-class enterprises is aggregated and curated for mobile readership into a language people can understand and trust.