Dengue Vaccines

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Last reviewed
November 22, 2022

Dengue Vaccines

The World Health Organization and the U.S. FDA recommend dengue vaccines should be given to persons with confirmed prior dengue virus infection in dengue-risk areas. As of October 30, 2022, there are now two authorized dengue vaccines in the world.

The U.S. FDA authorized the Dengvaxia vaccine for limited use in May 2019 for people with laboratory-confirmed previous dengue infection and living in dengue-endemic areas. On June 24, 2021, the U.S. CDC's Advisory Committee on Immunization Practices ACIP presented updated dengue vaccine considerations. And on October 20, 2022, the ACIP reviewed an UPDATE on Dengvaxia and Dengue Epidemiology: Globally and U.S.

And as of August 22, 2022, Takeda's QDENGA® dengue vaccine was approved in Indonesia and is pending in Europe. The FDA granted priority review on November 22, 2022.

Dengue Outbreaks

For the latest information on dengue outbreaks, visit this web page.

Dengue Vaccines U.S. CDC

On October 20, 2022, Wilbur Chen, MD, MSc, led the CDC's ACIP Dengue Vaccine Workgroup presentation. The U.S. CDC's Laura Adams, DVM, MPH, and Liliana Sánchez-González, MD, MPH, presented ' Clinician Outreach and Communication Activity Call on September 29, 2022. Three doses of the Dengvaxia vaccine are indicated for the prevention of dengue in people 9–16 years old with laboratory confirmation of previous dengue virus infection and living in dengue-endemic areas. 

Dengue Vaccines Approved

Dengvaxia (CYD-TDV, Dengue Tetravalent Vaccine, Live) is a live attenuated tetravalent chimeric vaccine made using recombinant DNA technology by replacing the PrM (pre-membrane) and E (envelope) structural genes of yellow fever attenuated 17D strain vaccine and is indicated for the prevention of dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Patients must receive a lab test showing a past infection with dengue before receiving the vaccine.

QDENGA® (TAK-003) is a dengue vaccine based on a live-attenuated dengue serotype two virus, which provides the genetic “backbone” for all four dengue serotypes and is designed to protect against any virus serotype. QDENGA is the only dengue vaccine approved for use in individuals regardless of previous dengue exposure and without needing pre-vaccination testing. In Long-Term Exploratory Analysis, TAK-003 Prevented 84% of Hospitalizations and 61% of Symptomatic Dengue Illness, with No Identified Important Safety Risks.

Dengue Vaccine Candidates

The DV1-DV4 vaccine candidate is transitioning into a human clinical study. This new vaccine construct, which comprises Nature's gene-chip peptides bound to a quantum cluster gold nanoparticle delivery system, was shown to have an excellent safety profile in a repeat dose Good Laboratory Practice grade toxicology study using a standard industry model.

TetraVax-DV-TV003 is a live attenuated recombinant tetravalent investigational dengue vaccine. Dr. Stephen Whitehead's laboratory developed the vaccine at NIH's National Institute of Allergy and Infectious Diseases.

Àvida Biotech's novel oral vaccine candidate for dengue does not require cold transport or storage and has completed proof of concept in a mouse model. In addition, the University of Buffalo's Center for Integrated Global Biomedical Sciences will provide preclinical drug development expertise.

Merck V180 (V181) is a Phase I Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Tetravalent Recombinant Subunit Dengue Vaccine (V180) in Healthy Adults. The US FDA has granted V181, the Company's investigational dengue vaccine in Phase 1 development, Fast Track designation.

K.M. Biologics KD-382 vaccine is a live attenuated tetravalent dengue vaccine candidate in phase 1 clinical trial that is expected to be effective against all four serotypes with a single dose. In addition, this live attenuated virus vaccine is expected to induce neutralizing antibodies and cellular immunity, similar to natural infection.

Emergex PepGNP-Dengue vaccine candidate uses 100% synthetic vaccines to 'prime' naive CD8+ T-Cells to generate virus-specific CTL (CD8+ Cytotoxic T Lymphocyte cells) to kill infected cells before productive viral infection, thus preventing viral replication and disease in the vaccinated person. The Last Visit per clinical trial protocol was performed on 11 March 2022. Phase I/II and II/III Clinical trials for vaccine candidates are planned.

CodaVax-DENV is a next-generation tetravalent dengue vaccine candidate under development by Codagenix Inc., whose vaccine design platform has enabled precise and rational attenuation of contemporary serotypes of all four strains of dengue virus through selective codon deoptimization. With this approach, Codagenix can rationally balance all four virus serotypes to produce a safe and highly immunogenic vaccine.

Dengue Vaccine Price

Pricing for Dengvaxia® is $99, and other dengue vaccines, such as QDENGA®, have not been disclosed. The CDC's Vaccine for Children fund supports eligible people. And UNICEF offers various support programs worldwide. Additional vaccine discount information is posted at InstantRx™.

Dengvaxia Laboratory Testing Requirements For 2022

Laboratory confirmation of previous dengue virus infection is required pre-Dengvaxia vaccination. It can be obtained by: Evidence of prior acute dengue virus infection with a positive dengue RT-PCR test result or positive dengue NS1 antigen test result. Additionally, positive results on BOTH of the following anti-dengue virus immunoglobulin G (dengue IgG antibody) tests in a two-step testing algorithm: EUROIMMUN Anti-Dengue Virus NS1 Type 1-4 ELISA (IgG) and CTK BIOTECH OnSite Dengue IgG Rapid.

The U.S. CDC stated that on December 22, 2021, 'A single positive anti-dengue virus immunoglobulin M test result is not sufficient proof of dengue virus infection for a vaccination with Dengvaxia due to potential cross-reactivity other circulating flaviviruses (Zika virus) in dengue-endemic areas.

Dengue Vaccine News For 2020 - 2022

November 22, 2022 - Currently, TAK-003 has not been approved by the U.S. FDA or any other health authority other than Indonesia.

October 14, 2022 - Europe's human medicines committee recommended granting marketing authorization for the QDENGA Dengue Tetravalent Vaccine (Live, Attenuated) for the prevention of dengue virus serotypes 1, 2, 3, and 4 in people from four years of age. 

August 22, 2022 - The Indonesia National Agency for Drug and Food Control, Badan Pengawas Obat dan Makanan approved the QDENGA® dengue vaccine.

August 17, 2022 - Codagenix Inc. announced the U.S. DoD granted the Company a $4.4 million award to progress the development of CodaVax-DENV, its tetravalent dengue vaccine candidate.

July 1, 2022 - Emergex Vaccines Holding Limited announced that it had signed heads of terms for a collaboration with the Molecular Biology Institute of Paraná in Brazil, with a focus on dengue vaccinations.

June 30, 2022- A new study identifies a specific scent emitted from dengue-infected mice that attract mosquitos.

June 20, 2022 - France reported from May to June 17, 2022, 39 imported cases of dengue fever were identified in metropolitan France. 

June 15, 2022 - The Minister for Sustainability and the Environment, Ms. Grace Fu, announced at the Asia Dengue Summit that the National Environment Agency will be releasing male Wolbachia-carrying Aedes aegypti mosquitoes in 1,400 additional blocks across Singapore from July 2022. The releases are expected to reduce the urban Aedes aegypti mosquito population (dengue vector) in these high-risk areas.

June 14, 2022 - The journal Scientific Reports published: Disruption of spatiotemporal clustering in dengue cases by wMel Wolbachia in Yogyakarta, Indonesia - Introgression of wMel Wolbachia into Aedes aegypti mosquito populations interrupts focal dengue virus transmission leading to reduced case incidence; the true intervention effect may be greater than the 77% efficacy measured in the primary analysis of the Yogyakarta trial.

      June 9, 2022 - Takeda's TAK-003 is Undergoing Regulatory Review for Potential Licensure in the European Union and Select Dengue-Endemic Countries.

      June 7, 2022 - CNN reported Singapore had exceeded 11,000 dengue cases as of June 1, 2022, far beyond the 5,258 it reported throughout 2021.

      May 22, 2022 - The Minister of Health of São Tomé and Príncipe declared an outbreak of dengue fever in May 2022, becoming the first reported outbreak in the country.

      May 5, 2022 - Anitoa Systems announced the availability of an RT-PCR solution for testing the dengue virus. This turn-key solution includes one of a family of 4-6 channel small foot-print real-time PCR instruments called the Maverick qPCR, with a one-step multiplex RT-PCR reagent offered in lyophilized format. The multiplex test detects several target genes in a sample, which are shown by researchers to be highly expressed in patients that later develop serious symptoms.

      May 4, 2022 - The Lancet confirmed the OnSite IgG RDT should provide a valuable tool for screening for previous dengue infection at the point of vaccination. In individuals who were OnSite IgG RDT-positive, the vaccine efficacy of CYD-TDV was high across all three age groups.

      April 18, 2022 - Emergex Vaccines Holding Limited updated its first-in-human clinical trials of its Dengue and Coronavirus T cell Adaptive Vaccine candidates. The Company completed the Phase I clinical trial for its novel CD8+ T cell Dengue vaccine candidate. 

      April 13, 2022 - The media reported Ahmedabad Municipal Corporation in India had confirmed 37 cases of dengue in 2022.

      March 18, 2022 - BMC Virology Journal published research: Circulation of genotypes of dengue virus serotype 2 in Guangzhou over a period of 20 years. Conclusions: In Guangzhou, local control of the DENV-2 epidemic requires effective measures to prevent and monitor imported cases. Moreover, the shift between the Malaysia/Indian subcontinent genotype lineages, which originated at different time points, may account for the rise in DENV-2 cases in Guangzhou. Meanwhile, the low rate of dengue hemorrhagic fever in Guangzhou may be explained by the dominance of the less virulent Malaysia/Indian subcontinent genotype.

      March 17, 2022 - The South Delhi Municipal Corporation in India confirmed 55 dengue cases reported this year until March 26, 2022, and 35 cases have been marked as "untraced after investigation" due to incomplete or wrong addresses provided by patients and hospitals.

      March 2, 2022 - The Lancet published a study: Measuring the effects of COVID-19-related disruption on dengue transmission in Southeast Asia and Latin America: a statistical modeling study. Interpretation - COVID-19-related disruption led to historically low dengue incidence in most countries in 2020. However, continuous monitoring of dengue incidence as COVID-19-related restrictions are relaxed will be important and could give new insights into transmission processes and intervention options.

      March 2, 2022 - The Lancet published a commentary - Movement dynamics: reduced dengue cases during the COVID-19 pandemic.

      February 24, 2022 - BMC reported that the number of dengue cases recorded nationwide in Sri Lanka represented a 74% reduction from the predicted number of dengue cases for March 2020 to April 202d. 

      February 23, 2022 - The U.S. CDC issued a Watch - Level 1, Practice Usual Precautions, for Dengue in Asia and the Pacific Islands.

      February 3, 2022 - EUROIMMUN announced that the U.S. CDC cited its EUROIMMUN® Anti-Dengue Virus NS1 Type 1-4 ELISAC as part of the two-step testing algorithm guidance for pre-vaccination screening for the Dengvaxia® vaccine that is used to prevent future dengue disease.

      January 4, 2022 - The U.S. CDC issued a Level 1 Travel Advisory for people visiting Bangladesh, India, Pakistan, and Sri Lanka.

      December 16, 2021 - The JAMA Network published a Viewpoint: Vaccination for Dengue Prevention: Physicians practicing in dengue-endemic areas of US territories and affiliated states can take the first steps in promoting health equity by implementing screen-and-vaccinate programs among children 9 to 16 years old.

      December 14, 2021 - The WHO reported dengue is endemic in Pakistan. From January to 25 November 2021, a total of 48,906 cases, including 183 deaths (case fatality ratio (CFR): 0.4%), have been reported from four provinces, including Punjab, Khyber Pakhtunkhwa, Sindh, Balochistan, and the federally administered Islamabad Capital Territory, and Azad Jammu and Kashmir autonomous territories, Pakistan.

      November 14, 2021 - Haryana confirmed three dengue deaths, reported the Times of India. At 8,819, the official dengue count in Haryana is the highest in five years.

      October 28, 2021 - The Times of India confirmed a dengue outbreak has impacted about 300 people and caused several deaths in rural areas of Roorkee and Bhagwanpur.

      October 13, 2021 - The journal PLOS published: Economic impact of dengue in Singapore from 2010 to 2020 and the cost-effectiveness of Wolbachia interventions. Wolbachia releases in Singapore are expected to be highly cost-effective, and its rollout must be prioritized to reduce the onward spread of the dengue virus in humans.

      October 9, 2021 - BMC Infectious Disease published: Clinical predictors of severe dengue: a systematic review and meta-analysis. Conclusions - Our meta-analysis identified children, secondary infection, diabetes, and renal disease(s) as important predictors of severe dengue. Our finding also supports the predictive ability of the WHO warning signs to identify severe dengue. These findings are useful for clinicians to identify severe dengue for management and timely interventions.

      October 6, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced in collaboration with the K.U. Leuven Rega Institute and the K.U. Leuven Centre for Drug Design and Discovery, the publication of new preclinical data in the journal Nature showing that an early-stage compound with a novel mechanism of action could potentially treat all serotypes of dengue fever and provide a period of protection against acquiring the dengue virus. Janssen is now moving its dengue program into clinical development. Data from the early-stage study suggest that an antiviral compound prevents the interaction between two viral proteins (NS3 and NS4B) that play an important role in the replication process of a virus, thereby stopping the ability of the virus to reproduce. This represents an entirely novel mechanism of antiviral action.

      October 5, 2021 -  The Tamil Nadu Health Department has reported 2,930 dengue cases in 2021 and of this, 337 are active. Around 20 cases are reported per day in the state. Unfortunately, there have also been two deaths.

      October 4, 2021 - Clinical Infectious Diseases published: Three years efficacy and safety of Takeda's dengue vaccine candidate (TAK-003), which concluded by stating 'TAK-003 was efficacious against symptomatic dengue over three years. Efficacy declined over time but remained robust against hospitalized dengue.'

      September 30, 2021 - The U.S. CDC issued Watch - Level 1, Practice Usual Precautions Alerts regarding dengue outbreaks in Africa, Asia, the Americas, the Middle East, and the Pacific Islands.

      September 24, 2021 - The BMC Network published Krisztian Magori, who provides an update on the most recent developments in the use of Wolbachia in reducing dengue infections in Indonesia, with very encouraging results.

      September 23, 2021 - Principal Secretary Health Mr. Alok Shekhar stated that an upsurge in dengue cases has been reported in Punjab, India, with 1,724 confirmed cases from across Amritsar, Hoshiarpur, Sri Muktsar Sahib, SAS Nagar, Bathinda, and Pathankot. As a result, the Government of Punjab has increased the number of testing labs to 39. He added that testing and treatment of dengue is free of cost in all Government hospitals.

      September 23, 2021 - A non-peer-reviewed study: Immune profile and responses of a novel Dengue DNA vaccine encoding EDIII-NS1 consensus design based on Indo-African sequences. Dengue DNA platform focusing on Indo-African sequences offers an approach for assessing cross-reactive immunity in animal models and lays the foundation for human vaccine roll out either as a stand-alone or mix and match strategy.

      September 13, 2021 - Miss Universe Philippines 2021 contracts dengue and withdraws from the competition.

      September 9, 2021 - The WHO published Update #628 on Dengue in the Western Pacific Region. As of epidemiological week 33, a total of 10 deaths due to dengue have been reported in 2021, compared to 113 deaths during the same period in 2020.

      September 8, 2021 - India's local media reported preliminary figures to show UP's Firozabad is one district confronting dengue virus outbreaks. As many as 105 new dengue and viral fever cases were reported on September 5, 201. In addition, the death toll is reported to have mounted to 55, with most casualties being children.

      August 24, 2021 - Atea Pharmaceuticals announced data demonstrating the in vitro and in vivo activity of AT-752 against dengue virus infection in the journal, Antimicrobial Agents and Chemotherapy. The published data demonstrate that AT-752 has potent in vitro activity against multiple dengue virus serotypes and other flaviviruses tested, reduces viremia, and improves survival in an animal model of dengue disease.

      August 20, 2021 - The International Journal of Infectious Diseases published a study: Serotype and genotype diversity of dengue viruses circulating in India: A multicentre retrospective study involving virus research diagnostic laboratory network during 2018. The results revealed DENV-2 as the most prevalent serotype in many states. In addition, Thrombocytopenia, petechiae, and malaise were associated with DENV-2 infection. Phylogenetic analyses of DENV E gene sequences revealed the circulation of genotypes I and V of DENV-1, two lineages of DENV-2 genotype IV, DENV-3 genotype III, and DENV-4 genotype-I.

      July 12, 2021 - The Lancet published an article: Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation. 'To improve our understanding of the diverse factors that shape the clinical spectrum of disease resulting from dengue virus infection, prospective, community-based and clinic-based immunological, virological, genetic, and clinical studies across a range of ages and geographical regions are needed.'

      July 5, 2021 - New Delhi local media reported the South Delhi Municipal Corporation India revealed the number of dengue cases (36) from January 1 to July 3, 2021, is the highest this year since 2018.

      June 30, 2021 - Emergex Vaccines Holding Limited announced that it had achieved regulatory approval for a Phase I clinical trial of its PepGNP-Dengue vaccine. The study has received approval from Swiss regulatory agencies, and the first participants are expected to be enrolled soon.

      June 25, 2021 - The ACIP committee met to review the Acceptability and Implementation of dengue vaccines in Puerto Rico.

      June 24, 2021 - UNC School of Medicine scientists led by Aravinda de Silva, Ph.D., identified the small subpopulation of antibodies in vaccinated children that correlate with protection against dengue fever. This research, published on May 18, 2021, should help shape better vaccines for one of the most widespread infectious diseases in the world.

      June 11, 2021 - In Réunion, French authorities have reported 20,800 confirmed dengue cases for 2021, with the whole territory affected. This represents an increase of 4,602 cases since the last report with data as of May 25, 2021. Among the hospitalized dengue cases, 20% had severe dengue, a slightly higher proportion than in 2019 (17%) and 2020 (16%). Twelve deaths are considered directly related to dengue.

      June 10, 2021 - The NEJM reported a fatal case of dengue in Florida. 'Ensuring appropriate patient care management, including close clinical monitoring and judicious use of intravenous fluids, can reduce dengue case-fatality rates. Therefore, clinicians should suspect dengue and order molecular testing for patients with acute febrile illness and relevant epidemiologic exposure because knowledge of this infection may alter clinical care.'

      June 10, 2021 - The NEJM published 'Efficacy of Wolbachia-infected Mosquito Deployments for the Control of Dengue.' This study concluded 'Introgression of wMel into A. aegypti populations effectively reduced the incidence of symptomatic dengue and resulted in fewer hospitalizations for dengue among the participants.'

      May 22, 2021 - Takeda Pharmaceutical announced that TAK-003 demonstrated continued protection against dengue illness and hospitalization, regardless of an individual's previous dengue exposure.

      May 6, 2021 - The U.S. CDC issued a Level 1 Travel Alert regarding dengue outbreaks in South and Central America, Mexico, and the Caribbean. 

      May 5, 2021 - The U.S. CDC's ACIP committee Gabriela Paz Bailey, MD, Ph.D., MSc presented 'Dengue Vaccine Evidence to recommendations framework.'

      April 12, 2021 - Review Article: Dengue Virus and Vaccines: How Can DNA Immunization Contribute to This Challenge?

      April 2, 2021 - French media reported, 'With 758 cases of dengue confirmed from March 15 to 21, the epidemic is accelerating on Reunion Island. Twenty municipalities are concerned with groupings of cases mainly located in the West at Port, Saint-Paul, and La Possession, and in the South at Saint-Joseph. To date, only serotype 1 has been detected among the confirmed cases.

      March 31, 2021 - In 2021, and as of week #12, the Pan American Health Organization had reported 175,372 suspected and confirmed dengue cases and 32  associated deaths in the Americas region. The five countries reporting the most cases are Brazil (130,013), Nicaragua (9,207), Peru (7 953), Colombia (7,247), Paraguay (6,938). In addition, all four dengue virus serotypes (DENV 1, DENV 2, DENV 3, and DENV 4) are currently circulating in the region of the Americas, which increases the risk of severe cases. The figures for each country of the Americas region can be found on the PAHO Health Information Platform.

      March 25, 2021 - Takada announced the European Medicines Agency is conducting the First-Ever Parallel Assessment of a Medicinal Product, Takeda's Dengue Vaccine Candidate (TAK-003), for use in the E.U.; Countries Outside of the E.U. through the EU-M4all (Previously Article 58) Procedure. Furthermore, Takeda Intends to Submit Regulatory Filings in Argentina, Brazil, Colombia, Indonesia, Malaysia, Mexico, Singapore, Sri Lanka, and Thailand during 2021.

      March 25, 2021 - Japan-based KM Biologics Co., Ltd. announced Phase I clinical study of a live attenuated tetravalent vaccine, KD-382, to prevent dengue. The results show that the KD-382 vaccine is safe and well-tolerated by healthy adults. Moreover, KD-382 showed 100% seroconversion early and elicited long-lasting and neutralizing antibody response for all 4 serotypes in most subjects over a 1-year follow-up, despite the single-dose administration. Based on the supporting results indicating the KD-382 vaccine as very promising, the Company is preparing for Phase II clinical studies.

      March 3, 2021 - The U.S. CDC reported 5 dengue cases had been confirmed in the USA during 2021. And U.S. Territories (Puerto Rico) have confirmed 85 dengue cases.

      March 2, 2021 - The U.S.CDC issued a Level 1 Travel Alert for many parts of Central and South America, Mexico, and the Caribbean regarding Dengue virus risks. 

      February 25, 2021 - The Lancet published a systematic review and meta-analysis of Risk predictors of progression to severe disease during the febrile phase of dengue. This analysis supports monitoring of the warning signs described in the 2009 WHO guidelines on dengue. Also, testing for infecting serotype and monitoring platelet count and serum albumin, AST, and ALT concentrations during the febrile phase of illness could improve the early prediction of severe dengue.

      December 4, 2020 - Researchers from the United Kingdom announced they used plants to produce virus-like particles (VLPs) of the dengue virus in a potential first step towards novel vaccines against the growing threat.

      November 30, 2020 - The South American country of the Republic of Peru has resumed most transportation options, including airport operations. In addition, other improved conditions such as the resumption of most business operations and a gradual re-opening of borders have been reported within Peru. 

      November 16, 2020 - Study published by The Lancet: Accuracy and efficacy of pre-dengue vaccination screening for previous dengue infection with five commercially available immunoassays: a retrospective analysis of phase 3 efficacy trials. Each immunoassay's specificity and sensitivity were determined as percentage negative and positive, compared with the reference algorithm, which used dengue plaque reduction neutralization test with 50% and 90% cutoffs and nonstructural protein 1 IgG ELISA results to assign baseline serostatus. These findings suggest that these immunoassays could be used for pre-vaccination screening for CYD-TDV as tools to assist risk stratification until more sensitive and convenient tests become available.

      November 16, 2020 - A new study published by The Lancet found 'Previous trials have provided some evidence that antibody responses elicited after just one dose or two doses of CYD-TDV might be similar to those elicited after three doses. They compared antibody responses following one-dose, two-dose, and three-dose vaccination regimens in dengue seropositive individuals at baseline up to 1 year after the last injection. They reported that a 2-dose CYD-TDV regimen might be an alternative to the licensed 3-dose regimen in dengue seropositive individuals at baseline and aged 9 years and older. Vaccination with a reduced number of doses could improve vaccine compliance and coverage, especially in low-resource settings.

      November 16, 2020 - Study: A prospective population-based study will determine dengue virus serostatus by indirect IgG ELISA compared with focus reduction neutralization test in children in Cebu, Philippines. Compared with FRNT, ELISA had high sensitivity and specificity (>90%), but the false-negative and false-positive rates make the test suboptimal for prevaccination screening. Individuals falsely identified as seropositive by dengue IgG ELISA and then vaccinated might be at risk of developing the severe disease during subsequent exposure to wild-type dengue virus. Those with a monotypic profile would benefit the most from vaccination. Still, the IgG ELISA's sensitivity was much lower in this group than in those with a multitypic profile.

      November 9, 2020 - Clinical trial: Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America. Dengue vaccine does not enhance symptomatic Zika illness in dengue-seropositive individuals; rather, it reduces the risk of virologically confirmed Zika. In addition, Zika infection boosts preexisting vaccine-induced or naturally occurring dengue-neutralizing antibodies.

      November 4, 2020 - The University of Buffalo's Center for Integrated Global Biomedical Sciences (CIGBS) will partner with Àvida Biotech, a Spain-based developer of antiviral products, to advance affordable, new antivirals and vaccines for neglected infectious diseases such as the dengue. The CIGBS scientists will support Àvida Biotech's investigation of a novel oral vaccine for dengue that does not require cold transport or storage.

      October 27, 2020 - According to new clinical trials conducted in Iquitos, Peru, Spatial repellents can reduce the risk of infected people with Aedes mosquito-borne viruses. According to the University of Notre Dame, the Peru trial results are encouraging — study participants whose houses contained the spatial repellent were 34 percent less likely to become infected with Aedes mosquito-borne viruses than other study participants who received the placebo product without the repellent. The Iquitos trial was part of a multi-year effort led by scientists at the University of Notre Dame to determine the protective efficacy of spatial repellents to prevent human infection with pathogens that cause diseases such as malaria, Zika, and dengue, spread through mosquito bites.

      October 25, 2020 - Study: Plant‐made dengue virus‐like particles produced by co‐expression of structural and nonstructural proteins induce a humoral immune response in mice. These results are consistent with the idea that VLPs could be optimal for creating candidate vaccines against enveloped viruses.

      October 14, 2020 - The U.S. CDC issued a Level 1 Travel Alert for the Americas. Dengue is an ongoing risk in many parts of Central and South America, Mexico, and the Caribbean (map). Travelers to areas of risk should protect themselves by preventing mosquito bites.

      September 22, 2020 - The Florida Department of Health in Miami-Dade County (DOH-Miami-Dade) is under a mosquito-borne illness alert. A case of dengue fever of local transmission has been confirmed in a Miami-Dade resident. There has been a total of two locally acquired dengue cases in 2020.

      September 21, 2020 - The authors of a non-peer-reviewed study hypothesized that a safe and effective dengue vaccine could offer some immunity against SARS-CoV-2.

      August 27, 2020 - The World Mosquito Program (WMP) of Monash University and its Indonesian partners, the Tahija Foundation and Universitas Gadjah Mada have announced the first results of a cluster randomized controlled trial of its Wolbachia method, showing a 77% reduction in the incidence of virologically-confirmed dengue in Wolbachia-treated areas of Yogyakarta, Indonesia, compared to untreated areas. 

      July 23, 2020 - The Florida Department of Health (DOH) recently issued a mosquito-borne illness alert following the detection of locally-acquired dengue fever cases in Monroe County, the jurisdiction that includes the Florida Keys in South Florida.

      July 13, 2020 - Long-term safety and immunogenicity of a tetravalent dengue vaccine candidate in children and adults: a randomized, placebo-controlled, phase 2 study.

      June 23, 2020 - A Phase 1, Open-Label- Assessment of a Dengue Virus-1 Live Virus Human Challenge - (DENV-1-LVHC) Strain.

      March 17, 2020 - Results published in the first paper from an 18-month analysis of an ongoing pivotal Phase 3 trial were generally consistent with overall efficacy and safety data reported in the previously published 12-month analysis.

      November 6, 2019 - New England Journal of Medicine publishes primary endpoint analysis from an ongoing Phase 3 study of Takeda's dengue vaccine candidate. TAK-003 was efficacious against symptomatic dengue in countries in which the disease is endemic. 

      August 23, 2019 - Study: Pre-vaccination screening strategies for using the CYD-TDV dengue vaccine: A meeting report. The meeting discussions highlighted many challenges in introducing Dengvaxia, screening test characteristics, costs of such tests combined with a 3-dose schedule, logistics, high coverage rates, vaccine confidence, and communication; more challenges than any other vaccine introduction program.

      November 14, 2018 - Preliminary data regarding a live-attenuated tetravalent dengue vaccine candidate developed by Takeda show that the vaccine may protect against all four serotypes of the infection, according to research presented at the annual meeting of the American Society of Tropical Medicine and Hygiene.

      Dengue Virus Antigen Detection

      NS1 tests detect the nonstructural protein NS1 of the dengue virus. This protein is secreted into the blood during dengue infection. NS1 tests have been developed for use in serum. Most of these tests use synthetically labeled antibodies to detect dengue NS1 protein, says the U.S. CDC.

      Dengue Overview

      Dengue is a mosquito-borne viral infection that is common in warm, tropical climates. Infection is caused by any one of four closely related dengue viruses (called serotypes). These can lead to a wide spectrum of symptoms, including extremely mild to those that may require medical intervention and hospitalization, says the Florida Department of Health.

      Dengue virus (DENV) is responsible for an estimated 100 million symptomatic cases of infection and 10,000 deaths annually. The incidence of dengue has been doubling every decade since 1990.

      Dengue is common in the U.S. territories of Puerto Rico, the U.S. Virgin Islands, and American Samoa, says the U.S. CDC.

      Note: The content on this webpage is aggregated from the WHO, the U.S. CDC, research studies, and various media sources. Healthcare providers like Dr. Bob Carlso review this content for efficacy.