Clinical Trial Info

EPIC-Peds: Study of Oral PF-07321332 (Nirmatrelvir)/Ritonavir in Nonhospitalized COVID-19 Pediatric Patients at Risk for Severe Disease

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The purpose of the Phase 3 study is to evaluate the safety, pharmacokinetics, and efficacy of nirmatrelvir/ritonavir for the treatment of nonhospitalized, symptomatic pediatric participants with coronavirus disease 2019 (COVID-19) who are at risk of progression to severe disease.

140 pediatric participants (up to 18 years old) will be recruited for this study.

Inclusion criteria:

  • Male/female
  • Able to swallow tablets
  • Positive SARS-CoV-2 infection within 5 days prior to enrollment
  • At least 1 characteristic or underlying medical condition that could increase the risk of developing severe COVID-19 illness