MMR Vaccine May Soon Have a Competitor
97% of children had a positive seroresponse against the 3 MMR-RIT Priorix components
A study published in the Pediatric Infectious Disease Society concluded saying, ‘if licensed, the Priorix / MMR-RIT vaccine could provide a valid option for the prevention of measles, mumps, and rubella in children, 12-to 15-months-old in the United States.
Additionally, these researchers said the ‘Priorix / MMR-RIT vaccine would reduce potential risks of a future vaccine shortage'.
In this new study, the researchers assessed the immunogenicity and safety of the Priorix / MMR-RIT vaccine from GlaxoSmithKline (GSK) was compared with those of the existing measles vaccine market leader, MMR II, which is produced by Merck.
In this phase IIIa, observer-blinded, non-inferiority, lot-to-lot consistency clinical trial NCT01702428, 5,003 healthy children were randomly assigned to receive 1 dose of MMR-RIT (1 of 3 production lots) or MMR II along with other age-recommended routine vaccines.
The immune responses after vaccination with MMR-RIT were reported to be robust and non-inferior to those after vaccination with the MMR II.
And, the immunogenicity of the 3 production lots of MMR-RIT was consistent; with more than 97 percent of the children had a seroresponse to MMR components.
The co-administered vaccines elicited similar immune responses in the MMR-RIT and MMR II groups.
Both MMR vaccines resulted in comparable reactogenicity profiles, and these researchers reported that approximatively 13 percent of the children experienced a rash related to vaccination, which was slightly higher than the incidence reported in other studies of MMR vaccines.
The Priorix / MMR-RIT vaccine works by causing the human body to produce its own protective antibodies against these diseases. Priorix is generally given as a single 0.5 mL dose. The same dose is used for children and adults, says GSK.
Measles, mumps, and rubella are all infectious diseases caused by viruses. All of these diseases are spread person-to-person through the air.
The diseases are very contagious but are preventable with appropriate immunization.
- Immunogenicity and Safety of a Measles-Mumps-Rubella Vaccine Administered as a First Dose to Children Aged 12 to 15 Months
- Consistency Study of GlaxoSmithKline (GSK) Biologicals' MMR Vaccine (209762) (Priorix) Comparing Immunogenicity and Safety
- Immunogenicity and Safety Study of GSK Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Ye
- Immunogenicity and safety of measles-mumps-rubella vaccine at two different potency levels administered to healthy children
- Immunogenicity and safety of a second dose of a measles-mumps-rubella vaccine administered to healthy participants 7 or older
- Safety and immunogenicity of an upper-range release titer measles-mumps-rubella vaccine in children vaccinated at 12 to 15 month
- Measles, mumps, and rubella are serious diseases...Make sure your child is protected!