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Which Ebola Vaccines and Treatments Are Approved?

October 7, 2022 • 3:06 am CDT
U.S. Dept of State
(Precision Vaccinations News)

Currently, vaccines and treatments are approved by the U.S. Food and Drug Administration (FDA) targeting the Ebola virus disease (EVD) caused by the Zaire Ebolavirus, but not the Sudan species. 

As of October 7, 2022, the FDA, the U.S. CDC, and the World Health Organization are collaborating on developing Sudan Ebolavirus vaccines and treatments for use in Uganda.

Vaccine candidates focused on the Sudan Ebolavirus have conducted early-stage clinical trials and are expected to proceed with experimental human studies in the Republic of Uganda in October 2022.

Uganda's ongoing Sudan Ebolavirus outbreak has expanded with a case-fatality rate of over 40%.

To alert visitors to central Africa, the U.S. CDC has issued a Level 2 Travel Health Notice due to Ebolavirus disease in the following districts:  Mubende, Kassandra, Kyegegwa, Kagadi, and Bunyangabu.

Regarding Zaire Ebolavirus, the U.S.FDA approved the Ervebo® vaccine on December 19, 2019.

And a two-dose vaccine regimen of a different vaccine was used under a research protocol in 2019 during an Ebola outbreak in the Democratic Republic of the Congo.

The two doses of this vaccine use different vaccine components, Zabdeno (Ad26.ZEBOV) and Mvabea (MVA-BN-Filo).

This regimen requires an initial dose and a booster dose 56 days later. 

Additionally, there are currently two treatments* approved by the U.S. FDA to treat EVD in adults and children caused by the Zaire ebolavirus.

These monoclonal antibody treatments (mAbs) bind to a portion of the Ebola virus's surface called the glycoprotein, which prevents the virus from entering a person's cells.

The first mAbs was approved in October 2020, Inmazeb™ is a combination of three monoclonal antibodies.

The second single mAbs, Ebanga™, was approved in December 2020.

mAbs are proteins produced in a lab or manufacturing facility that act like natural antibodies to stop a germ, such as a virus, from replicating after it has infected a person.

Other Ebola outbreak news is posted at Vax-Before-Travel.

Our Trust Standards: Medical Advisory Committee

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