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COVID-19 Antibodies Persist Sometimes

July 19, 2021 • 3:44 pm CDT
(Precision Vaccinations)

Researchers from the University of Padua and Imperial College London tested more than 85% of the 3,000 residents of Vo', Italy, in February/March 2020 for infection with SARS-CoV-2, the coronavirus that causes COVID-19. They re-tested in May and November 2020 for antibodies against the virus.

The team found that 98.8% of people infected showed detectable levels of antibodies in November 2020.

Furthermore, there was no difference between people who had suffered symptoms of COVID-19 and those that had been symptom-free.

Antibody levels were tracked using three 'assays' - tests that detect different types of antibodies that respond to different parts of the virus. The results showed that while all antibody types showed some decline between May and November, the decay rate was different depending on the assay.

The team also found cases of antibody levels increasing in some people, suggesting potential re-infection with the virus, providing a boost to the immune system.

Lead author Dr. Ilaria Dorigatti, from the MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics (J-IDEA) at Imperial, said in a press release: "We found no evidence that antibody levels between symptomatic and asymptomatic infections differ significantly, suggesting that the strength of the immune response does not depend on the symptoms and the severity of the infection.

"However, our study does show that antibody levels vary, sometimes markedly, depending on the test used."

"This means that caution is needed when comparing estimates of infection levels in a population obtained in different parts of the world with different tests and at different times."

Professor Enrico Lavezzo from the University of Padua said: "The May testing demonstrated that 3.5% of the Vo' population had been exposed to the virus, even though not all of these subjects were aware of their exposure given the large fraction of asymptomatic infections.

"However, at the follow-up, which was performed roughly nine months after the outbreak, we found that antibodies were less abundant, so we need to continue to monitor antibody persistence for longer time spans."

The team also investigated the infection status of household members to estimate how likely an infected member is to pass on the infection within the household. Their modeling suggests that there was a probability of about 1 in 4 that a person infected with SARS-CoV-2 passes the infection to a family member and that most transmission (79%) is caused by 20 percent of infections.

This study's finding confirms large differences in the number of secondary cases generated by infected people. The majority of infections generate no further infections, and a minority of the infections generate many infections.

The large differences in how one infected person may infect others in the population suggest that behavioral factors are key for epidemic control, and physical distancing, as well as limiting the number of contacts and mask-wearing, continue to be important to reduce the risk of transmitting the disease, even in highly vaccinated populations.

The team's dataset, which includes the results of the two mass PCR testing campaigns conducted in February and March and the antibody survey conducted in May and then again in November, also allowed them to tease apart the impact of various control measures.

They showed that manual contact tracing alone would not have been enough to suppress the epidemic without case isolation and short lockdowns.

Project lead Professor Andrea Crisanti, from the Department of Life Sciences at Imperial and the Department of Molecular Medicine at the University of Padua, said: "Our study also shows that manual contact tracing - the search for positive individuals based on known and declared contacts - would have had a limited impact on the containment of the epidemic, had it not been accompanied by a mass screening."

Dr. Dorigatti added: "It is clear that the epidemic is not over, neither in Italy nor abroad."

"Moving forward, I think that it is of fundamental importance to continue administering first and second vaccine doses and strengthen surveillance, including contact tracing. In addition, encouraging caution and limiting the risk of acquiring SARS-CoV-2 will continue to be essential."

Note: The researchers acknowledge Abbott, DiaSorin, and Roche Diagnostics for kindly supplying reagents with no influence on the study design and data analysis. The Veneto Region supported this work.