2021–2022 Influenza Season

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Last reviewed
April 10, 2021

2021-2022 Influenza Vaccine Composition


Northern Hemisphere FLu Season Vaccines

The World Health Organization (WHO) has recommended the Northern Hemisphere 2021–2022 influenza vaccine composition. The Food and Drug Administration’s Vaccines and Related Biological Products Advisory Committee (VRBPAC) subsequently made the influenza vaccine composition recommendation for the United States. 

The 2021–2022 U.S. influenza vaccines' composition includes updates to the influenza A(H1N1)pdm09 and influenza A(H3N2) components. These vaccine recommendations were based on several factors, including global influenza virologic and epidemiologic surveillance, genetic characterization, antigenic characterization, and the candidate vaccine viruses for production.

U.S. egg-based influenza vaccines are recommended to contain the following:

  • A/Victoria/2570/2019 (H1N1)pdm09-like virus
  • A/Cambodia/e0826360/2020 (H3N2)-like virus
  • B/Washington/02/2019 (B/Victoria lineage)-like virus
  • B/Phuket/3073/2013 (B/Yamagata lineage)-like virus (for quadrivalent vaccines)

U.S. cell- or recombinant vaccines are recommended to contain the following:

  • A/Wisconsin/588/2019 (H1N1)pdm09-like virus
  • A/Cambodia/e0826360/2020 (H3N2)-like virus
  • B/Washington/02/2019 (B/Victoria lineage)-like virus
  • B/Phuket/3073/2013-like (B/Yamagata)-like virus (for quadrivalent vaccines)

On March 30, 2021, the European Medicines Agency issued recommendations for the influenza virus strains that vaccine manufacturers should include in vaccines to prevent seasonal influenza from autumn 2021.

Southern Hemisphere Flu Season Vaccines

Australia: The Australian Technical Advisory Group on Immunisation (ATAGI) has released advice for immunization providers in its Statement on the administration of seasonal influenza vaccines in 2021. Flu vaccines through the National Immunisation Program (NIP) will become available in April 2021. Timing may be different for your local area. 

This year both flu and COVID-19 vaccines will be available in Australia. It is important to plan vaccination timing to give the best protection against both of these potentially serious diseases. There is advice for vaccination providers in the Statement on the relative timing of administering influenza vaccines and COVID-19 vaccines in 2021.

Southern Hemisphere Flu Season News

April 1, 2021 - Minister for Health and Wellbeing Stephen Wade said immunization providers have begun to receive stock of the influenza vaccination, helping protect the South Australian community from this deadly disease.